… of APOC3 mutations with coronary heart disease in … between APOC3 level and the risk
of coronary heart disease, … participants in the Framingham Heart Study offspring cohort (…

… disease and ischemic heart disease. Second, we tested whether loss-of-function mutations
in APOC3, which were associated with reduced levels of nonfasting triglycerides, were also …

… Finally, using mediation analysis, we determined the fraction of the observed lower risk of
IVD and ischemic heart disease (IHD) associated with APOC3 loss-of-function …

… postprandial triglyceride concentrations. The finding that a loss-of-function mutation in
APOC3 is associated with reduced triglyceride concentration is in agreement with the well-known …

… For mutations associated with triglycerides, we subsequently evaluated association …
mutations in the apolipoprotein C-III (APOC3) gene was associated with lower plasma triglycerides…

… also reduce risk for clinical atherosclerotic cardiovascular disease (ASCVD) (2,3). Here, we
address 2 questions related to mutations that reduce APOC3 function: 1) do these mutations …

… loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides
(… to verify the cardioprotective role of earlier reported six LoF variants of APOC3 in South …

… apoC-III was shown to be positively associated with development of coronary heart disease.
In addition, LDL-bound apoC-III was … Loss-of-function mutations in APOC3, triglycerides, and …

… to mutations in APOC3, associate with reduced risk of ischemic cardiovascular disease in …
low levels of nonfasting triglycerides were associated with reduced risk of ischemic vascular …

… drugs is known to cause increased coronary artery disease risk. Here, we studied genes
representing molecular targets of coxibs to detect signals for coronary artery disease (CAD) in a …